The IWS1 antibody from Wuhan Fine Biotech Co., Ltd. is a Rabbit Polyclonal antibody to interacts with SUPT6H, CTD assembly factor 1, and IWS1. This antibody recognizes Homo Sapiens, Human, Mouse, and Rat antigen. The IWS1 antibody has been validated for the following applications: EIA, Immunoassay, Precipitation, ELISA, Immunoprecipitation, and Western Blot.
Description
Transcription factor which plays a key role in defining the composition of the RNA polymerase II(RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain(CTD) of the RNAPII subunit RPB1(POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors(ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes(such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription